Research Funding
![image](assets/img/funder-logos/convergence-health.png)
![image](assets/img/funder-logos/nih-long.jpg)
![image](assets/img/funder-logos/hubmap-long.png)
![image](assets/img/funder-logos/hollandptc.jpg)
Research Partners
![image](assets/img/partner-logos/tudelft.jpg)
![image](assets/img/partner-logos/vanderbilt.jpg)
![image](assets/img/partner-logos/lumc.png)
![image](assets/img/partner-logos/erasmus.jpg)
Research Interests
We design algorithms to understand gene regulation and DNA damage and repair, to characterize disruptions of these processes in disease, and to discover therapeutic targets.
Computer Science
- Algorithms
- Machine learning
- Data mining
- combinatorial algorithms
- n-way clustering
- time course analysis
- domain-driven data integration
Molecular biology
- Transcriptional regulation
- Epigenetic regulation
- DNA damage and repair
- Gene expression
- TF-DNA binding
- Epigenomics
- Gene disruption and editing readouts (CRISPR + sequencing)
- Gene essentiality
- Mutation patterns and signatures
Biomedicine (cancer)
Focus on disruption of relationships and pathways rather than single functional elements (i.e. genes).
- Major regulation of disrupted pathways.
- Mechanisms involved in drug resistance.
- Gene essentiality and synthetic lethality relationships.
- DNA damage and repair.